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Gelbard M, Goldstein I, Hellstrom WJ et al: Clinical efficacy, safety and tolerability of collagenase clostridium histolyticum for the treatment of peyronie disease in 2 large double-blind, randomized, placebo controlled phase 3 studies

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

Without any clear rationale, the study outcome measures were purposefully modified midtrial to alter the findings in favour of their hypothesis (549, 550)